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Got the following in my vagrant system.  Reloading the page succeeded.

Fatal error: Call to a member function real_escape_string() on a non-object in includes/db/DatabaseMysqli.php on line 187


 Call Stack: 0.0067 642016
 1. {main}() index.php:0
 2. MediaWiki->run() /vagrant/mediawiki/index.php:49
 3. MWExceptionHandler::handle() includes/Wiki.php:470 
 4. MWExceptionHandler::report() includes/Exception.php:678 
 5. MWException->report() includes/Exception.php:606
 6. DBConnectionError->reportHTML() includes/Exception.php:259 
 7. MWException->reportHTML() includes/db/DatabaseError.php:222
 8. DBConnectionError->getPageTitle() includes/Exception.php:225
 9. DBConnectionError->msg() includes/db/DatabaseError.php:148
 10. Language->getMessage() includes/db/DatabaseError.php:129
 11. LocalisationCache->getSubitem() languages/Language.php:2337
 12. LocalisationCache->loadSubitem() includes/cache/LocalisationCache.php:281
 13. LCStore_DB->get() includes/cache/LocalisationCache.php:379
 14. DatabaseBase->selectRow() includes/cache/LocalisationCache.php:1097
 15. DatabaseBase->select() includes/db/Database.php:1585
 16. DatabaseBase->selectSQLText() includes/db/Database.php:1494
 17. DatabaseBase->makeList() includes/db/Database.php:1546
 18. DatabaseBase->addQuotes() includes/db/Database.php:1966
 19. DatabaseMysqlBase->strencode() includes/db/Database.php:2366
 20. DatabaseMysqli->mysqlRealEscapeString() includes/db/DatabaseMysqlBase.php:455